Stepanova, Anna N.

Plant and Microbial Biology
atstepan@ncsu.edu
919-515-5729
919-515-3355 fax
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Using Arabidopsis as a model system, I am investigating the molecular mechanisms behind the phenotypic plasticity of plants. Although the signal integration field in plant biology is still in its infancy, it is becoming increasingly clear that phytohormones are at the center of the signal integration and interpretation process. My lab is utilizing a combination of traditional genetic and modern molecular and genomic approaches to explore the role of two hormones, ethylene and auxin, in the signal integration process in plants. Their previous studies identified a new point of crosstalk between these hormones, induction of auxin biosynthesis by ethylene, and uncovered a previously uncharacterized indole pyruvic acid route of auxin production. I am continuing the search for the missing components of the ethylene and auxin pathways with the goal to fill in the numerous gaps in the understanding of hormone signaling and response in plants. Recent forward genetic screens in our lab yielded a number of novel mutants affected in their response to ethylene and/or auxin. We are in the process of cloning and characterizing several of these mutant lines in hope to determine their role in the signal integration process in plants.
 
Expertise:
  Plant Genomics and Genetics
Country(s) of experience:
  Austria | China-Peoples Rep | Germany | Japan | Sweden |
Type(s) of International Experience:
  Speaker at an international conference | Other international activities | Advisor for international students | Host for international faculty | Host for international post-doc
Language(s):
  Russian | Spanish
Projects:
  Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity
01/01/2010 - 01/01/2010
Funding Agency/Sponsor:
Institutional Partner: Umeå Plant Science Centre (UPSC), Sweden
  Local auxin sources orient apical-basal axis in Arabidopsis embryos
01/01/2010 - 01/01/2010
Funding Agency/Sponsor:
Institutional Partner: Institute of Science and Technology Austria (IST)
  Kinetic analysis of Arabidopsis glucosyltransferase UGT74B1 illustrates a general mechanism by which enzymes can escape product inhibition
01/01/2010 - 01/01/2010
Funding Agency/Sponsor:
Institutional Partner: Leibniz Institute of Plant Biochemistry, Germany
  A Small-Molecule Screen Identifies L-Kynurenine as a Competitive Inhibitor of TAA1/TAR Activity in Ethylene-Directed Auxin Biosynthesis and Root Growth in Arabidopsis
01/01/2010 - 01/01/2010
Funding Agency/Sponsor:
Institutional Partner: Peking University, China
  The Arabidopsis YUCCA1 Flavin Monooxygenase Functions in the Indole-3-Pyruvic Acid Branch of Auxin Biosynthesis
01/01/2010 - 01/01/2010
Funding Agency/Sponsor:
Institutional Partner: Umeå Plant Science Centre (UPSC), Sweden