Daub, Margaret E

Plant and Microbial Biology
margaret_daub@ncsu.edu
919-513-6986
919-515-3436 fax
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Research efforts in my laboratory focus on the molecular biology of interactions between fungal pathogens of plants and their hosts, with an emphasis on the role of toxins and reactive oxygen species in pathogenicity. A major area of interest focuses on fungi in the genus Cercospora and the role of their photoactivated toxin cercosporin in disease development. Cercosporin generates reactive oxygen species that damage host cells and allow for successful pathogenesis. We are isolating and characterizing genes from the fungus that encode resistance to cercosporin, both to understand the molecular basis of toxin resistance as well as for engineering Cercospora-resistant plants using tobacco as a model system. Another project focuses on the role of light-activated toxins in the Black Sigatoka disease of banana, caused by Mycosphaerella fijensis. We are identifying polyketide gene clusters in the M. fijiensis genome and are characterizing the products and their role in disease development. Our goal is to gain an understanding of fungal pathogenicity factors and to use this information for the development of disease-resistant plants.

 
Expertise:
  Plant Genomics and Genetics | Plant Transformation/Regeneration | Microbiology | Molecular Biology | Plant Physiology | Plant Pathology
Country(s) of experience:
  Brazil | Costa Rica | Egypt
Type(s) of International Experience:
  Researcher in an international project | Speaker at an international conference | Other international activities | Host for international faculty | Host for international post-doc
Projects:
  Development of Resistance to Cercospora Diseases of Crops
01/01/2011 - 12/31/2016
Funding Agency/Sponsor: U.S. Department of Agriculture (USDA)
Institutional Partner: Fayoum University, Egypt | Sugar Crops Research Institute (SCRI), Egypt
  Global Plant Health Study Abroad Program
01/01/2011 - 12/31/2016
Funding Agency/Sponsor: National Science Foundation (NSF)
Institutional Partner: Universidad Nacional de Costa Rica