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2012 - 11th Annual NC State Summer Undergraduate Research Symposium
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Session Time :
8/1/12 1:30 PM - 8/1/12 2:45 PM
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Content Area : Research Experience for Undergraduate Mathematics: Modeling and Industrial Applied Mathematics
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Lead Student Presenters : Mia Sato Tackney
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Co-Presenters :
Kaitlyn Ferguson
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Co-Presenters :
Patrick Daniels
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Co-Presenters :
Kheri Hicks
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Abstract Title : Cardiac baroreflex in humans and rats: mathematical modeling of complex physiological mechanisms
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Abstract :
The regulation of blood pressure by the cardiovascular system is an intricate and extensive process. In the afferent component, baroreceptors detect changes in arterial pressure and relay signals to the central nervous system. In the efferent component, sympathetic and parasympathetic nerves control heart rate response. While empirical investigation alone into this system poses difficulties, mathematical modeling can provide qualitative and quantitative insight into essential physiological mechanisms.
Firstly, we test a recently developed baroreceptor model for its ability to fit data and demonstrate known pressure-response relationships. Secondly, we propose an improved model of the heart rate with an increased capacity to fit data. The integration of the baroreceptor model with the heart rate model results in a comprehensive representation of the cardiovascular system. Lastly, parameters of the overall model are estimated across distinct strains of rats and compared between rats and humans.
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Mentor and/or Co-Author : Adam Mahdi
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