NCSU CALS Biology -Profiles


This program is moving to the College of Sciences on July 1, 2013, as part of the new Department of Biological Sciences. This page will remain available for a period of time after that date, but please note that the permanent home for the latest information on this program is at the new department’s website at bio.sciences.ncsu.edu.

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Dr. Carolyn Mattingly

Associate Professor
Campus Box 7617
North Carolina State University
Raleigh, North Carolina 27695

David Clark Lab, Office #142

Phone 919-515-1509, 919-515-2024
Fax 919-515-5327
cjmattin@ncsu.edu
Comparative Toxicogenomics Database (CTD)

Education

B.A., Oberlin College
Ph.D., Tulane University


Biography
Dr. Mattingly received a B.A. in Art History from Oberlin College. She attended Tulane University and received a Ph.D. in molecular toxicology where she investigated the effects of TCDD on vertebrate development. She then pursued postdoctoral training at the Weill Medical College of Cornell University where she investigated the effects of retinoids on differentiation in prostate epithelial cells and mechanisms by which environmental chemicals, including AHR ligands, interfered with retinoid signaling. 

Research
My laboratory is interested in understanding the complex interactions between our environment and human health. Specifically, we use bioinformatics and comparative genomics approaches to identify and explore molecular pathways that are affected by environmental exposures. Better understanding about these pathways will likely lead to improvements in regulation of exposures and treatment of environmentally influenced diseases. Specifically, we: a)  are developing the freely available Comparative Toxicogenomics Database (CTD; http://ctdbase.org), which contains curated and integrated data sets that facilitate development of novel hypotheses about the connections between chemicals, genes and proteins, and diseases; and b) using the zebrafish to dissect pathways that we predict are perturbed by exposures to ubiquitous environmental contaminants like TCDD, bisphenol A and arsenic.  


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