With time, inflammation can become a chronic condition that causes continuous damage to adipose, muscle, and connective tissues. During chronic inflammatory immune responses, tissue injury and healing proceed simultaneously and lead to severe tissue deterioration, thus underpinning the lifestyle and age-related diseases. We seek to discover novel molecular targets and develop effective nutritional strategies against inflammation and age-related diseases in preclinical models and clinical human studies targeting metabolic, cardiovascular, microbiome, and age-related outcomes. The gained knowledge will position us at the forefront of human health research, allow us to capitalize on synergistic interdisciplinary expertise, generate data to support joint proposals, allow for student and young faculty mobility, and ultimately lead to new treatments for patients with chronic lifestyle and age-related diseases.