CALS International Programs

Barrangou, Rodolphe

Associate Professor Food, Bioprocessing and Nutrition Sciences
rodolphe_barrangou@ncsu.edu
919-513-1644

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Research Interests

Our laboratory focuses on the biology and genetics of CRISPR-Cas immune systems in bacteria. Using microbiology, molecular biology and genomics approaches, we investigate the use of CRISPR-Cas systems for three types of applications:

1. Exploitation of CRISPR spacer hypervariability for genotyping and phylogenetic studies of beneficial and pathogenic bacteria
2. Leveraging CRISPR-mediated interference for building up phage resistance in probiotic strains and starter cultures used in food manufacturing
3. Harnessing of Cas9-mediated, re-programmable dsDNA cleavage for genome editing in bacteria

These activities provide insights into the genetic and molecular processes that drive CRISPR-mediated adaptive immunity in bacteria, and generate novel tools for the manipulation of industrially relevant organisms for food and biotechnological applications.

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Expertise:
Animal Genomics and Genetics | Bioinformatics | Plant Genomics and Genetics | Food Science | Microbiology | Molecular Biology

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Country(s) of experience:
Canada | China-Peoples Rep | Denmark | Finland | France | Lithuania | Netherlands

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Type(s) of International Experience:
Researcher in an international project | Speaker at an international conference | Director of study abroad programs or similar | Other international activities | Host for international post-doc

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Language(s):
French

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Projects:
CRISPR immunity Research project
01/01/2014 - 12/31/2015
Funding Agency/Sponsor:
Institutional Partner: DuPont, USA

CRISPR-Cas9 cleavage Research project
01/01/2009 - 12/31/2013
Funding Agency/Sponsor:
Institutional Partner:

CRISPR book Research project
01/01/2012 - 12/31/2012
Funding Agency/Sponsor:
Institutional Partner: Wageningen University and Research Centre (Wageningen UR), Netherlands

CRISPR adaptive immunity Research project
01/01/2007 - 12/31/2012
Funding Agency/Sponsor:
Institutional Partner: Université Laval, Canada

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Project Collaborations:
Development of methods for knockout chickens
01/01/2015 - 01/01/2016
Funding Agency/Sponsor: National Institute of Food and Agriculture (NIFA)
Institutional Partner: