Smallholder farming practices in sub-Saharan Africa (SSA) include land-raised seed (piece) use, continuous cultivation (often monoculture) with limited inputs, and virtually non-existent seed (piece) treatment techniques. Yam (Dioscorea spp.) is the primary example of this cropping system and is an extremely important and valuable crop for smallholder farmers in SSA. These practices result in nutrient-depleted soils, nematode infestation, and ultimately low crop yields. Reducing the nematode population in crop soil will dramatically increase crop yield and quality. In many cases, smallholder farmers in SSA lose greater than 50% of their crop to plant-parasitic nematodes, primarily due to lack of available and affordable control options. For this BMG GCE Phase III proposal, we will build upon our promising results from Phase II trials, including increased yields and higher tuber quality and storability for both yam and potato, and use our expertise and connections for pulping banana fiber to validate and prepare for commercialization a developing-world transferable product platform enabling a field deployable paper-like seed (piece) treatment to combat plant pathogenic nematodes. In addition, this platform will be amenable to delivering other crop production moieties, including natural products and oils, necessary minerals and nutrients, or insecticides and fungicides, with its application. Our laboratories’ expertise in nematology and lignocellulosic fibrous materials enables us to target the delivery of beneficial small molecules during seed (piece) germination and plant establishment. Importantly the incorporation of active ingredients into a lignocellulose matrix, such as banana tissue paper, allows for widespread distribution of crop protection agents without interfering in smallholder farming practices. The shelf-stable light-weight banana tissue paper can be applied at the point of seed (piece) planting where farmers can use the concept of “wrap and plant” with their own seeds/pieces. Our candidate ‘wrap and plant’ product will be an “active” paper sheet pretreated with ultralow concentrations of active nematicidal ingredient to simply wrap and protect the seed (piece) at planting. The localization of active ingredients carried directly within the paper targets specific plant pathogenic nematodes versus beneficial organisms. Nematodes are primarily a seedling disease, so protection early is critical to the success of the crop, although post harvest losses do occur in yam due to the yam nematode (Scutellonema bradys). Reduction in nematode populations by deploying ‘wrap and plant’ will protect yam from significant infections that may lead to these post-harvest losses. Our ultimate goal is to validate the ‘wrap and plant’ candidate in Phase III and prepare to translate manufacture to a regional African company for commercialization and distribution.